Pyrroloquinoline quinone (PQQ), a natural bioactive substance, is a water-soluble redox coenzyme that is considered to be a new B vitamin

1. PQQ的膳食补充有改善血脂水平，控制血糖浓度的潜在效果。

吡咯喹啉醌（PQQ）是一种天然生物活性物质，是一种水溶性氧化还原辅酶，被认为是一种新型B族维生素PQQ广泛分布于多种膳食来源中，具有潜在的健康益处，如抗炎、抗氧化，抗糖尿病和心脏保护作用。 多项研究表明，PQQ 缺乏会导致免疫功能障碍、生长障碍和繁殖性能异常。哺乳动物不能合成 PQQ，因此，膳食补充 PQQ 对于维持人类健康至关重要。 一些研究表明，PQQ 可以保护心脏免受氧化应激损伤、心肌缺血/再灌注损伤、肥厚和心力衰竭。 目前，PQQ对DCM的保护作用及其相关机制尚不清楚。 研究首次证明PQQ可显着减轻糖尿病小鼠的心肌损伤，包括心肌纤维化和心肌肥厚。 此外，PQQ 被发现可以抑制糖尿病小鼠和高糖处理的 AC16 细胞中 NF-κB/细胞焦亡信号通路的激活。

 使用 40 毫克/公斤/天的 PQQ 治疗可显着降低糖尿病小鼠的血糖浓度，但对体重没有影响.(表二) Treatment with 40 mg/kg/day PQQ significantly reduced the blood glucose concentrations of diabetic mice, but had no effect on body weight. 

Pyrroloquinoline quinone (PQQ), a natural bioactive substance, is a water-soluble redox coenzyme that is considered to be a new B vitamin  PQQ is distributed widely in multiple dietary sources and exhibits potential health benefits, such as anti-inflammatory , anti-oxidative，anti-diabetic, and cardioprotective effects. Several studies have demonstrated that PQQ deficiency leads to immune dysfunction, growth impairment, and abnormal reproductive performance  Mammals do not synthesize PQQ and, therefore, dietary supplementation with PQQ is essential for maintaining human health. Some studies have shown that PQQ protects the heart against oxidative stress injury , myocardial ischemia/reperfusion injury, hypertrophy and heart failure. However, the protective effect of PQQ against DCM and the associated mechanism are not clear. This study has demonstrated for the first time that PQQ significantly alleviated myocardial damage, including myocardial fibrosis and myocardial hypertrophy, in diabetic mice. Further, PQQ was found to inhibit the activation of the NF-κB/pyroptosis signaling pathway in diabetic mice and high glucose-treated AC16 cells.

2.PQQ在2小时和24小时处理后对脂质含量的不同影响，即自由脂肪酸水平的降低

该研究展示了PQQ在2小时和24小时处理后对脂质含量的不同影响，即自由脂肪酸水平的降低。 PQQ对特定脂质部分含量和组成以及胰岛素抵抗L6肌管中参与脂质代谢的酶表达的影响，PQQ 和 PGC-1α 在脂肪酸酯化为特定脂质库（例如 TAG 和 CER）中的作用，分别是保护性部分和有害部分，以实现适当的细胞功能。

 The impact of short- (2 h) and long-term (24 h) exposure to PQQ on particular lipid fraction content and composition as well as the expression of enzymes involved in lipid metabolism in insulin-resistant L6 myotubes is described herein.

参考1：Supruniuk E, Mikłosz A, Chabowski A. Pyrroloquinoline Quinone Modifies Lipid Profile, but Not Insulin Sensitivity, of Palmitic Acid-Treated L6 Myotubes. Int J Mol Sci. 2020 Nov 8;21(21):8382. doi: 10.3390/ijms21218382. PMID: 33171690; PMCID: PMC7664924.

参考2：Qu XF, Zhai BZ, Hu WL, Lou MH, Chen YH, Liu YF, Chen JG, Mei S, You ZQ, Liu Z, Zhang LJ, Zhang YH, Wang Y. Pyrroloquinoline quinone ameliorates diabetic cardiomyopathy by inhibiting the pyroptosis signaling pathway in C57BL/6 mice and AC16 cells. Eur J Nutr. 2022 Jun;61(4):1823-1836. doi: 10.1007/s00394-021-02768-w. Epub 2022 Jan 8. PMID: 34997266; PMCID: PMC9106599.