The Promising Application Prospects of Nervonic Acid

Nervonic acid, also known as 24:1n-9 or C24:1n-9, is a long-chain monounsaturated fatty acid. It belongs to the omega-9 fatty acid family and is primarily found in the brain's white matter. Over the years, numerous scientific studies have shed light on the potential application prospects of nervonic acid in various fields. This article aims to explore these prospects, providing information sourced from reputable scientific journals and studies.

1. Neurological Disorders

Research has shown that nervonic acid plays a crucial role in maintaining optimal brain function.For instance, A study speculate the intervention of NA could be an effective way in improving cognitive impairment through the activation of PI3K signaling pathway. These results suggest that NA has the potential to be developed as antioxidant drug for the prevention and early therapy of AD. (Reference 1). Other studies also have suggested that nervonic acid supplementation may be beneficial in the prevention and treatment of neurological disorders such as Alzheimer's disease, multiple sclerosis, and Parkinson's disease. (Reference 2)

2. Cognitive Enhancement

Nervonic acid has been associated with improved cognitive function and memory enhancement. A study published that nervonic acid supplementation improved learning and memory in animal models (Reference 3). These findings suggest that nervonic acid may hold promise as a cognitive enhancer, potentially benefiting individuals with age-related cognitive decline or cognitive impairments.

3.A Potential Therapy for Adrenoleukodystrophy

Nervonic acid is a long-chain monounsaturated fatty acid. A Study have shown their observations investigating nervonic acid, a monounsaturated fatty acid as a potential therapy for ALD. Adrenoleukodystrophy (ALD) is an X-linked inherited peroxisomal disorder due to mutations in the ALD protein and characterized by accumulation of very long-chain fatty acids (VLCFA), specifically hexacosanoic acid (C26:0). Study have shown that nervonic acid can reverse total lipid C26:0 accumulation in a concentration-dependent manner in ALD cell lines. Nervonic acid can be a potential therapeutic for individuals with ALD, which can alter cellular biochemistry and improve its function.(Reference 5)

The application prospects of nervonic acid are promising and diverse. From neuroprotective effects to cognitive enhancement and to a Potential Therapy for Adrenoleukodystrophythis fatty acid shows potential in various fields. However, further research is necessary to fully understand its mechanisms of action, optimal dosage, and potential side effects. With ongoing scientific exploration, nervonic acid may offer new avenues for therapeutic interventions and improve the quality of life for individuals in need.

References:

1. Aihaiti M, Shi H, Liu Y, Hou C, Song X, Li M, Li J. Nervonic acid reduces the cognitive and neurological disturbances induced by combined doses of D-galactose/AlCl3 in mice. Food Sci Nutr. 2023 Jul 6;11(10):5989-5998. doi: 10.1002/fsn3.3533. PMID: 37823115; PMCID: PMC10563680.

2. Hu, Dandong, Cui, Yujuan and Zhang, Ji. "Nervonic acid amends motor disorder in a mouse model of Parkinson’s disease" Translational Neuroscience, vol. 12, no. 1, 2021, pp. 237-246. https://doi.org/10.1515/tnsci-2020-0171

3. Song, Wangting & Zhang, Ke & Xue, Teng & Han, Jiarui & Ding, Chunguang & Peng, Fangda & Lin, Feng & Li, Jiujun & Agassi, Sze & Gan, Jianwen & Chen, Xianyang. (2022). Cognitive Improvement Effect of Nervonic Acid and Essential Fatty Acids on Rats Ingesting Acer truncatum Bunge Seed Oil Revealed by Lipidomics Approach. Food & Function. 13. 10.1039/D1FO03671H.

4. Terluk, M.R., Tieu, J., Sahasrabudhe, S.A. et al. Nervonic Acid Attenuates Accumulation of Very Long-Chain Fatty Acids and is a Potential Therapy for Adrenoleukodystrophy. Neurotherapeutics 19, 1007–1017 (2022). https://doi.org/10.1007/s13311-022-01226-7