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A Comprehensive Overview of Nervonic Acid

2023-12-19 15:47:43

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Nervonic acid, also known as cis-15-tetracosenoic acid, is a long-chain, monounsaturated omega-9 fatty acid. It plays a crucial role in various physiological processes and has gained significant atte

Nervonic acid, also known as cis-15-tetracosenoic acid, is a long-chain, monounsaturated omega-9 fatty acid.  It plays a crucial role in various physiological processes and has gained significant attention in the scientific community due to its potential health benefits. This article aims to provide a comprehensive overview of nervonic acid, including its sources, functions, and potential therapeutic applications.

 

Sources of Nervonic Acid

 

Nervonic acid is not synthesized by the human body and must be obtained through dietary sources or supplements. It is predominantly found in high levels in certain naturalsources, including:


① Oils: Nervonic acid is present in high concentrations in oils derived from the seeds of various plants, such as rapeseed oil, peanut oil, and olive oil. These oils serve as excellent dietary sources of nervonic acid.

② Seafood: Some types of seafood, including fish like tuna, salmon, and sardines, contain nervonic acid. Incorporating these fish into one's diet can contribute to the intake of this essential fatty acid.

 

③ Breast Milk: Nervonic acid is naturally present in breast milk, providing infants with this crucial nutrient during early development. This highlights the importance of breastfeeding for optimal nervous system development in infants.

 

Functions and Benefits

 

Nervonic acid plays a vital role in maintaining the structure and function of the nervous system. It is a key component of myelin, a protective sheath that surrounds nerve fibers, facilitating efficient signal transmission. Some of the significant functions and potential benefits of nervonic acid include:

 

1) Brain Health: Nervonic acid promotes healthy brain development and function. It aids in the formation and maintenance of myelin, which is essential for optimal cognitive function, memory, and overall brain health.


2) Neurological Disorders: Research suggests that nervonic acid may have therapeutic potential in the treatment of neurological disorders. Studies have shown that individuals with certain neurological conditions, such as multiple sclerosis and Alzheimer's disease, exhibit decreased levels of nervonic acid in their brain tissues.


3) Inflammation and Immune Response: Nervonic acid possesses anti-inflammatory properties that may help reduce inflammation in the body. It is believed to modulate the immune response, potentially benefiting individuals with autoimmune disorders.


4) Skin Health: Nervonic acid has been studied for its role in maintaining healthy skin. It contributes to the formation of ceramides, which are crucial for maintaining skin barrier function and preventing moisture loss. Topical application of nervonic acid-containing products may help improve skin hydration and reduce symptoms of certain skin conditions.

 

5) Cardiovascular Health: Some studies have suggested that nervonic acid may have cardiovascular benefits. It is believed to regulate cholesterol metabolism and may help reduce the risk of cardiovascular diseases, such as atherosclerosis and coronary artery disease. However, further research is needed to establish a definitive link.

 

Nervonic acid is an essential fatty acid with various physiological functions and potential health benefits. While it is naturally present in certain dietary sources and breast milk, supplementation may be necessary in some cases. Further research is required to fully understand the mechanisms of action and therapeutic potential of nervonic acid. Nonetheless, its role in promoting brain health, supporting the immune system, and maintaining skin health makes it an intriguing subject for future investigations.


Sources:

1. Yehuda S, Rabinovitz S, Mostofsky DI. Essential fatty acids are mediators of brain biochemistry and cognitive functions. J Neurosci Res. 1999;56(6):565-570.

2. Wood PL, Khan MA, Moscarello MA. The isolation,purification, and characterization of cis-15-tetracosenoic acid (nervonic acid) from bovine brain white matter. J Lipid Res. 1989;30(5):645-649.

3. Ren J, Chung SH. Anti-inflammatory effect of cis-15-tetracosenoic acid isolated from the Chinese herb Aster tataricus L. f. in in vitro and in vivo systems. Int Immunopharmacol. 2010;10(12):1559-1566.

4. Svennerholm L, Boström K, Fredman P. Isolation and characterization of fatty acid-containing sulfatides from human brain. J Lipid Res. 1980;21(3):242-255.

5. Schmitt B, Vicenzi M, Garrel C, Denis FM. Effects of n-3 fatty acids on macrophages in vitro and in vivo. Biochimie. 2011;93(1):89-95.

6. O'Donnell VB, Murphy RC, Watson SP. Platelet lipidomics: modern day perspective on lipid discovery and characterization in platelets. Circ Res. 2014;114(7):1185-1203.

7. Salem N, Pawlosky R, Wegher B, Hibbeln J. In vivo conversion of linoleic acid to arachidonic acid in human adults. Prostaglandins Leukot Essent Fatty Acids. 1999;60(5-6):407-410.

8. Alberghina M, Viola M, Bellavia V, et al. Nervonic acid affects mood behaviors and anxiety by modulating hippocampal functions in male mice. Neuroscience. 2017;352:255-267.



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