AMAZON BANS NMN, ANTI-AGING PQQ MORE POTENTIAL TO BE DISCOVERED

AMAZON BANS NMN,

ANTI-AGING PQQ MORE POTENTIAL TO BE DISCOVERED

In November 2022, the FDA announced “that NMN is no longer recognized a dietary supplement by manufacturers or retailers in the United States”, but “a drug or drug ingredient, that requires FDA approval.” On February 16, 2023, Amazon emailed all sellers, “Products that contain NMN as an ingredient can no longer be sold or distributed as a dietary supplement”, and will remove all dietary supplements containing NMN after March 13, 2023.

NMN has long been widely recognized as “the aging elixir" and is popular all over the world. NMN is excluded from dietary supplements in the US, while anti-aging dietary supplement demand remains strong. its golden partner, PQQ, has more potential to be discovered.

PQQ is pyrroloquinoline quinone, also called methoxatin. There are three derivatives of quinone type, semiquinone type and hydroquinone type according to the combination of electrons and hydrogen ions, and they can be transformed into each other through electron and proton transfer. Pyrroloquinoline quinone disodium salt is the one with better solubility, also known as water-soluble vitamins.

In the 1950s, Norwegian and British biologists discovered an important coenzyme factor. In 1979, American scientists named this coenzyme factor PQQ. It widely exists in natural foods, including animals, vegetables, fruits, grains, and various tissues of the human body, but the content is extremely low, and the highest content is about 140-180ug in breast milk. It plays a very important role in growth and development.

PQQ has obtained international authoritative certification from different countries and regions, and its security is widely recognized and accepted.

The first PQQ dietary supplement was approved in the United States in 2009.

In 2012, Canada Heath authorized PQQ as a natural health food.

In 2014, Japan’s MHLW certified PQQ as food ingredient.

In 2018, the EU approved PQQ as novel food.

In 2021, China approved PQQ as a new feed additive; in 2022, China approved PQQ as a new food raw material.

Nutrition scientist Dr. Bruce Ames published an article in Proceedings of the National Academy of Sciences in 2018, classified PQQ as a“longevity vitamin.” Ikue Mori, a professor of molecular neurobiology at Nagoya University in Japan, used nematodes with DNA sequences similar to humans, The research shows, PQQ extended the lifespan of wild-type C. elegans adults in a dose-dependent manner by 31%.

The importance and unique of PQQ is its ability to stimulate the production of healthy mitochondria and repair damaged ones. Mitochondria are organelles in eukaryotic cells that can provide energy for the human body. 90% of the body's energy is provided by mitochondria. Mitochondria are known as "energy power plants". Mitochondria primarily generate energy for the body through oxidative phosphorylation to produce adenosine triphosphate (ATP), where food nutrients are converted into energy.

Mitochondria play an important role in cell growth, aging or pathology. The essential difference between normal cells and senescent cells or even tumor cells is whether the mitochondria are normal. Metabolic activities in normal cells rely primarily on mitochondrial oxidative phosphorylation to generate ATP for energy, while the oxidative respiration efficiency of mitochondria in aging cells is very low. Glycolysis is enhanced and OXPHOS capacity is reduced in various cancer cells.

PQQ stimulates mitochondrial biogenesis through cAMP response element-binding protein and increases PGC-1a gene expression. Studies have shown that PQQ can increase the number of mitochondria in cells by 1.63 times.

In addition, PQQ can increase the expression and activity levels of Sirt1 and Sirt3 genes in HepG2 cells. Sirtuins (Sirt) 1 and Sirt3 are NAD+-dependent protein deacetylases known as longevity proteins. It helps regulate cellular health, prevents disease and age-related loss of function, and plays a role in extending lifespan.

Mitochondria will also be attacked by electron groups of "free radicals" in the body, resulting in damage and decreased energy supply. PQQ acts as a redox agent in cells, it is a strong antioxidant. One molecule of PQQ can undergo 20,000 beneficial redox cycling (Vc can only participate in about 4 cycles), which can effectively remove harmful free radicals and keep mitochondria healthy.

PQQ increases the number of healthy mitochondria in aging cells and repairs mitochondrial damage, which undoubtedly has the ability to maintain youth for a long time for the people facing aging.

Beside NMN, PQQ can also be combined with single or multiple ingredients, such as CoQ10, Phosphatidylserine(PS), Curcumin, Tetrahydrocurcumin, Berberine, Resveratrol, Rhodiola Rosea Extract, Collagen, Astaxanthin etc,. Of course, outside of the United States, the other countries and regions can still keep the golden combination of NMN and PQQ. They work together to increase the number and activity of mitochondria, which can help mitochondria or the body staying young, extend life span and improve life quality.

Shandong Yuanlitai Nutratech Co., Ltd has been producing PQQ with an exclusive patented synthesis technology, also an intermediate compound with independent intellectual property rights. The production process is dust-free, odorless, and emission-free, which meets the requirements of a green recycling economy; the finished product has high purity, unique crystal form with bright color, the manufacturing process is stable, no related substances (impurities) are produced.

Adhering to the spirit of Mount Tai, keeping knowledge accumulating and technology improving, serving mankind firmly, Shandong Yuanlitai Nutratech Co., Ltd is committed to providing people with better food ingredients..