Anti-cancer pioneers: apoptosis induction in breast cancer cells by L selenium-methyl selenocysteine_News_Shandong Yuanlitai Medical Technology Co. Ltd.

Anti-cancer pioneers: apoptosis induction in breast cancer cells by L selenium-methyl selenocysteine

2024-11-18 10:11:02

Selenium, an essential trace element, primarily exists in the body in the form of selenium-containing amino acids, withL-Se-methylselenocysteine（hencefore MSC） being a notable example. MSC has shown promise as an anti-cancer agent, notably inducing apoptosis in various cancer cells, including breast cancer cells. Breast cancer remains the most prevalent malignancy among women worldwide, with high rates of incidence and mortality. The abnormal proliferation and resistance to apoptosis in breast cancer cells contribute significantly to its progression and treatment resistance. Exploring the apoptotic effects of MSC could offer new insights and potential therapeutic strategies for managing breast cancer.

MSC对MDA-MB-231细胞凋亡影响

MSC对MDA-MB-231细胞SOD、GSH-Px活力、MDA水平影响

The research results indicate that MSC can reduce the activity of SOD and GSH-Px in MDA-MB-231 cells while increasing MDA levels, showing a dose- and time-dependent effect. This suggests that MSC induces oxidative stress in MDA-MB-231 cells by decreasing intracellular SOD and GSH-Px activities and increasing MDA levels, leading to oxidative damage and subsequent cell apoptosis. This finding is consistent with existing research on oxidative stress regulation mechanisms in tumor cell apoptosis.

参考：袁国海, 黄秋, 邵继红, 罗雅婕, 谢蒙蒙. 硒-甲基硒代半胱氨酸诱导乳腺癌细胞凋亡作用. 中国公共卫生, 2016, 32(9): 1183-1185.

Anti-cancer pioneers: apoptosis induction in breast cancer cells by L selenium-methyl selenocysteine

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