Exploring the Protective Effects of Fisetin Against Myocardial Ischemia-Reperfusion Damage

Myocardial ischemia-reperfusion injury refers to the damage that occurs to myocardial tissue when blood flow is restored after ischemia. This damage can manifest as reversible reperfusion-induced arrhythmias, myocardial stunning, and irreversible microvascular obstruction, as well as fatal myocardial reperfusion injury. The mechanisms of myocardial ischemia-reperfusion injury are complex, involving various cellular signaling pathways and biomarkers. Fisetin have shown significant advantages in cardiovascular diseases. Fisetin, as a natural flavonoid, has demonstrated potential in cardiovascular protection. Fisetin has effects such as inhibiting oxidative stress and reducing inflammation. This finding provides a new research direction for fisetin as a potential drug for treating myocardial ischemia-reperfusion injury and may offer new insights for the future treatment of cardiovascular diseases.

漆黄素降低心冠脉流出液中 CK-MB 的含量

漆黄素对MIRI心脏梗死面积的影响

The research results indicate that Fisetin significantly increases the left ventricular pressure rise and fall rate and perfusion rate, and notably reduces the incidence of ischemia-reperfusion myocardial infarction. Fisetin perfusion significantly restores tissue morphology and alleviates ischemia-reperfusion injury. Myocardial tissue damage releases intracellular CK-MB, and the level of CK-MB in coronary effluent reflects the extent of myocardial damage. The results show that Fisetin can reduce the myocardial enzyme content indicative of myocardial cell damage. Fisetin also lowers MDA expression and increases SOD and GSH levels, suggesting that it inhibits free radical reactions and enhances antioxidant activity against MIRI. In summary, Fisetin has restorative effects on heart function, inhibits oxidative reactions, reduces inflammatory responses, and exerts anti-apoptotic effects in MIRI, providing a pharmacological basis for developing it as a protective drug against MIRI.

参考：[1]KALOGERIS T,BAINES C P, KRENZ M. Ischemia/ reperfusion [J]. Compr Physiol, 2016,7(1) : 113-170.

[2]漆黄素对大鼠体外心肌缺血-再灌注损伤的影响 张秀娟，郝雯瑾，李德芳，王博，韩吉春，郑秋生（滨州医学院中西医结合学院，烟台264003）