The Journey of Fisetin: Exploring Its Potential Role in Cervical and Breast Cancer

Fisetin shows great potential with its extensive biological activities, especially in inhibiting the proliferation, invasion and metastasis of cervical cancer and breast cancer cells. Although further clinical research is needed to verify its curative effect, Fisetin is undoubtedly a natural compound with great development prospects and is expected to become an important supplement to tumor treatment.

fisetin can play an anti-ovary cancer role by inhibiting cell proliferation and inducing cell death. It is expected to become a safe and effective natural drug for the prevention and treatment of ovarian cancer.

After Fisetin acts on human ovarian cancer SKOV3 cells, cytochromatin aggregation and apoptosis are produced. Fisetin can induce the death of human ovarian cancer SKOV3 cells. The nude mouse transplant tumor model showed that the volume and quality of the transplanted tumor decreased significantly after the intervention of Fisetin. After the action of Fisetin, the expression of the apoptosis factor Bax in the transplanted tumor increased significantly, the expression of the anti-apoptotic protein Bcl-2 decreased significantly, and the apoptotic protein PARP was significantly sheared.

Fisetin inhibits the phosphorylation of p38 MAPK and destroys the nuclear transposition of NF-KB to reduce the expression of uPA, thus inhibiting the migration and invasion of human cervical cancer cells.

Fisetin inactivates the p38 MAPK pathway to inhibit the expression of upa.

Sources：Fisetin inhibits migration and invasion of human cervical cancer cells by down-regulating urokinase plasminogen activator expression through suppressing the p38 MAPK-dependent NF-к signaling pathway.